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  1. Dies ist die bislang umfangreichste Studie (Phase 3 randomisiert, prospektiv) in der Hyperthermie in Kombination mit ausschließlich Chemotherapeutika: Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study.Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem BC, Abdel-Rahman S, Daugaard S, Salat C, Wendtner CM, Vujaskovic Z, Wessalowski R, Jauch KW, Dürr HR, Ploner F, Baur-Melnyk A, Mansmann U, Hiddemann W, Blay JY, Hohenberger P; European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC-STBSG); European Society for Hyperthermic Oncology (ESHO). Lancet Oncol. 2010 Jun;11(6):561-70. doi: 10.1016/S1470-2045(10)70071-1. Epub 2010 Apr 29.
  2. JAMA Oncol. 2018 Feb 15. doi: 10.1001/jamaoncol.2017.4996. Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial. Issels RD1, Lindner LH1, Verweij J2, Wessalowski R3, Reichardt P4, Wust P5, Ghadjar P5, Hohenberger P6, Angele M7, Salat C1, Vujaskovic Z8, Daugaard S9, Mella O10, Mansmann U11, Dürr HR12, Knösel T13, Abdel-Rahman S1, Schmidt M14, Hiddemann W1, Jauch KW7, Belka C15, Gronchi A16; European Organization for the Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group and the European Society for Hyperthermic Oncology.
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  8. Jeeyun Lee, MD, PhD, Se Hoon Park, MD, Joon Oh Park, MD, Young Suk Park, MD, Jeong Il Yu, MD, Hee Chul Park, MD, PhD, Doo Ho Choi, MD, PhD, Jae Myoung Noh, MD, Dongryul Oh, MD, Jun Su Park, MD, Ji Hyun Chang, MD, Seung Tae Kim, MD, Ho Yeong Lim, MD, PhD, Won Ki Kang, MD Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer Radiat Oncol J 2016;34(1):34-44 http://dx.doi.org/10.3857/roj.2016.34.1.34 pISSN 2234-1900, eISSN 2234-3156
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  12. Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K. (2015) A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study. Cancer Med. Jun;4(6):834-43. doi: 10.1002/cam4.431. Epub 2015 Feb 9.
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  1. Editorial: Radiation and the Immune System: Current Knowledge and Future Perspectives.Lumniczky K, Candéias SM, Gaipl US, Frey B. Front Immunol. 2018 Jan 23;8:1933. doi: 10.3389/fimmu.2017.01933. eCollection 2017. No abstract available.
  2. The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia. Finkel P, Frey B, Mayer F, Bösl K, Werthmöller N, Mackensen A, Gaipl US, Ullrich E. Oncoimmunology. 2016 Jun 7;5(6):e1101206. doi: 10.1080/2162402X.2015.1101206. eCollection 2016 Jun.
  3. Old and new facts about hyperthermia-induced modulations of the immune system. Frey B, Weiss EM, Rubner Y, Wunderlich R, Ott OJ, Sauer R, Fietkau R, Gaipl US. Int J Hyperthermia. 2012;28(6):528-42. doi: 10.3109/02656736.2012.677933. Epub 2012 Jun 12. Review.
  4. Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages. Schildkopf P, Frey B, Ott OJ, Rubner Y, Multhoff G, Sauer R, Fietkau R, Gaipl US. Radiother Oncol. 2011 Oct;101(1):109-15. doi: 10.1016/j.radonc.2011.05.056. Epub 2011 Jun 23.
  5. Biological rationales and clinical applications of temperature controlled hyperthermia–implications for multimodal cancer treatments. Schildkopf P, Ott OJ, Frey B, Wadepohl M, Sauer R, Fietkau R, Gaipl US. Curr Med Chem. 2010;17(27):3045-57. Review.
  6. A review of immune therapy in cancer and a question: can thermal therapy increase tumor response? Joan M. C. Bull To cite this article: Joan M. C. Bull (2017): A review of immune therapy in cancer and a question: can thermal therapy increase tumor response?, International Journal of Hyperthermia
  7. Fever and the thermal regulation of immunity: the immune system feels the heat. Evans SS, Repasky EA, Fisher DT. Nat Rev Immunol. 2015 Jun;15(6):335-49. doi: 10.1038/nri3843. Epub 2015 May 15. Review.
  8. Temperature matters! And why it should matter to tumor immunologists. Repasky EA, Evans SS, Dewhirst MW. Cancer Immunol Res. 2013 Oct;1(4):210-6. doi: 10.1158/2326-6066.CIR-13-0118. Review.
  9. Issels RD (2008) Hyperthermia adds to chemother¬apy. Eur J Cancer 44(17):2546–2554
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